Applicationof DSC and NIRS to study the compatibility of metronidazole with differentpharmaceutical excipients |
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| Authors: | D. Kiss R. Zelkó Cs. Novák Zs. Éhen |
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| Affiliation: | (1) University Pharmacy, Department of Pharmacy Administration, Semmelweis University, Budapest, Hungary, 1092, Hőgyes E. u. 7–9;(2) Research Group of Technical Analytical Chemistry, Hungarian Academy of Sciences, Budapest University of Technology and Economics, Budapest, Hungary, 1111, Szt. Gellért tér 4;(3) Institute of General and Analytical Chemistry, University of Technology and Economics, Budapest, Hungary, 1111, Szt. Gellért tér 4 |
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| Abstract: | ![]()
The purpose of the present work was to study the compatibility of metronidazole with different pharmaceutical excipients (hydroxypropyl methylcellulose, poly(ethylene oxide), microcrystalline cellulose, dicalcium phosphate dihydrate, and anhydrous dicalcium phosphate) using differential scanning calorimetry and diffuse reflectance spectroscopy. Dicalcium phosphate dihydrate was the only excipient that showed interaction with metronidazole even before storage. Changes referring to a possible transition to dihydrate form were observed in the thermal curves of anhydrous dicalcium phosphate after four weeks of storage. Although dicalcium phosphate dihydrate can be replaced by the anhydrous form in pharmaceutical formulations, the observed transition might negatively influence the stability of dosage forms. |
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| Keywords: | anhydrous dicalcium phosphate compatibility dicalcium phosphate dihydrate DSC metronidazole NIRS |
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