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| 多金属氧化物立方纳米晶体的可控合成及其与朊蛋白的特异性相互作用 | |
| 引用本文： | 梁文婷,黄承志,马璐. 多金属氧化物立方纳米晶体的可控合成及其与朊蛋白的特异性相互作用[J]. 中国科学B辑, 2009, 39(6): 495-500 |
| 作者姓名： | 梁文婷 黄承志 马璐 |
| 作者单位： | 西南大学药学院;发光与实时分析教育部重点实验室; |
| 基金项目： | 科技部国家重大科学研究计划(批准号:2006CB9331003)资助 |
| 摘 要： | 研究表明，在有机小分子二甲基甲酰胺（DMF）的调控作用下Keggin型多金属氧化物在水溶液中形成规则的纳米立方体，随温度改变该纳米立方体转变为空心立方结构．该多金属氧化物纳米立方体可以与朊蛋白（PrP^c）相互作用，产生显著的光散射信号增强，且增强程度在3．36-840ng·mL^-1范围内与朊蛋白浓度呈线性关系． |
| 关 键 词： | 多金属氧化物 纳米立方体 二甲基甲酰胺 光散射光谱 朊蛋白 |
| 收稿时间： | 2008-11-22 |
| 修稿时间： | 2008-12-15 |
Controllable synthesis of polyoxometalates nanocubes and their specific interactions with prion proteins |
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| LIANG WenTing,HUANG ChengZhi , MA Lu College of Pharmaceutical Science,Education Ministry Key Laboratory of Luminescence , Real-Time Analysis,Southwest University,Chongqing ,China. Controllable synthesis of polyoxometalates nanocubes and their specific interactions with prion proteins[J]. Science in China(Series B), 2009, 39(6): 495-500 | |
| Authors: | LIANG WenTing HUANG ChengZhi & MA Lu College of Pharmaceutical Science Education Ministry Key Laboratory of Luminescence Real-Time Analysis Southwest University Chongqing China |
| Affiliation: | LIANG WenTing,HUANG ChengZhi & MA Lu College of Pharmaceutical Science,Education Ministry Key Laboratory of Luminescence , Real-Time Analysis,Southwest University,Chongqing 400715,China |
| Abstract: | It was found in this contribution that Keggin-type of polyoxometalates nanocubes could be formed in aqueous medium under the adjustment of dimethylformamide （DMF）, which could be changed from solid nanocubes to hollow ones with the increasing of temperature. Further investigations showed that this Keggin-type of polyoxometalates nanocubes can specifically interact with prion protein, and the light scattering signals were enhanced in proportional to the content of priori in the range of 3.36-840 ng.mL^-1. |
| Keywords: | polyoxometalates nanocubes dimethylformamide light scattering spectrum prion protein |
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