Selective hydrogenations of steroids catalyzed by heterogenized Ru complexes |
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| Authors: | ágnes Zsigmond Ramóna Madácsi Ferenc Notheisz Erzsébet Mernyák and and Ferenc Joó |
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| Institution: | (1) Department of Organic Chemistry and Organic Catalysis Research Group of the Hungarian Academy of Sciences, University of Szeged, 6720 Szeged, Dóm tér 8, Hungary;(2) Department of Organic Chemistry, 6720 Szeged, Dóm tér 8, Hungary;(3) Department of Organic Chemistry and Organic Catalysis Research Group of the Hungarian Academy of Sciences, University of Szeged, 6720 Szeged, Dóm tér 8, Hungary;(4) Department of Organic Chemistry, 6720 Szeged, Dóm tér 8, Hungary;(5) Institute of Physical Chemistry and Research Group on Homogenous Catalysis of the Hungarian Academy of Sciences, University of Debrecen, P.O.Box 7, 4010 Debrecen10. Hungary |
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| Abstract: | Summary RuCl2(PPh3)3], {RuCl2(TPPMS)2}2] and their heterogenized analogs were applied in the selective hydrogenation of 17-keto- and α,β-unsaturated ketosteroids.
In basic conditions these complexes selectively hydrogenated the C=O bonds, similarly to the results obtained in the case
of α,β-unsaturated aldehydes. A new method was developed for the synthesis of an expensive steroid alcohol, which can be prepared
traditionally in a more complicated way. |
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| Keywords: | steroids Selective hydrogenations Ru complexes |
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