Toward a total synthesis of peloruside A: enantioselective preparation of the C8-C19 region |
| |
| Authors: | Taylor Richard E Jin Meizhong |
| |
| Affiliation: | Department of Chemistry and Biochemistry and the Walther Cancer Research Center, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, IN 46556-5670, USA. taylor.61@nd.edu |
| |
| Abstract: | ![]()
An efficient synthetic sequence toward the C8-C19 region of peloruside A has been developed. The route is highlighted by a selective electrophilic cyclization reaction, a single-step epoxide ring-opening/methylation sequence, and a stereoselective Mukaiyama aldol reaction. [reaction: see text] |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
