| 水中吡喃并[2,3-d]嘧啶衍生物的洁净合成 |
| |
| 引用本文： | 李胜辉,高娜,李记太.水中吡喃并[2,3-d]嘧啶衍生物的洁净合成[J].有机化学,2009,12(3):466-469. |
| |
| 作者姓名： | 李胜辉 高娜 李记太 |
| |
| 作者单位： | 河北大学化学与环境科学学院,保定,071002 |
| |
| 基金项目： | 河北省自然科学基金，河北大学博士基金 |
| |
| 摘 要： | 以芳醛、丙二腈和2-氨基-4,6-二羟基嘧啶为原料, 以水为溶剂, 在80 ℃以苄基三甲基溴化铵为催化剂一步合成了一系列的吡喃并2,3-d]嘧啶衍生物, 产物的结构通过IR, 1H NMR和元素分析表征. 该方法反应条件温和、操作简单、收率高. 而且水作为反应溶剂具有廉价、安全、无污染、产物易于分离的优点.
|
| 关 键 词： | 吡喃并[2 3-d]嘧啶 苄基三甲基溴化铵 绿色合成 |
| 收稿时间： | 2008-6-6 |
| 修稿时间： | 2008-9-29 |
Clean Synthesis of Pyrano[2,3-d]pyrimidine and Its Derivatives in Aqueous Media |
| |
| LI Sheng-hui,GAO Na,LI Ji-tai.Clean Synthesis of Pyrano[2,3-d]pyrimidine and Its Derivatives in Aqueous Media[J].Chinese Journal of Organic Chemistry,2009,12(3):466-469. |
| |
| Authors: | LI Sheng-hui GAO Na LI Ji-tai |
| |
| Institution: | (College of Chemistry and Environmental Science, Hebei University, Baoding 071002) |
| |
| Abstract: | A series of pyrano2,3-d]pyrimidine derivatives were synthesized by the reaction of aromatic aldehyde, malononitrile and 2-amino-4,6-dihydroxylpyrimidine in the presence of benzyltrimethyl ammonium bromide in water at 80 ℃. The structures of the products were characterized by IR, 1H NMR spectra and elemental analysis. Compared with other synthetic methods, this method has the advantages of neutral conditions, high yields and simple work-up procedures. In addition, water as a green solvent gave some merits such as cheapness, safty, and non-pollution. |
| |
| Keywords: | pyrano[2 3-d]pyrimidine benzyltrimethyl ammonium bromide green synthesis |
| 本文献已被 维普 万方数据 等数据库收录！ |
| 点击此处可从《有机化学》浏览原始摘要信息 |
| 点击此处可从《有机化学》下载免费的PDF全文 |
|
