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Identification of a higher-order organozincate intermediate involved in Negishi cross-coupling reactions by mass spectrometry and NMR spectroscopy |
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| Authors: | Hunter Howard N Hadei Niloufar Blagojevic Voislav Patschinski Pascal Achonduh George T Avola Stephanie Bohme Diethard K Organ Michael G |
| Affiliation: | Department of Chemistry, York University, 4700 Keele St., Toronto, M3J 1P3, Canada. |
| Abstract: | Negishi cross-coupling reactions were analyzed in solution by mass spectrometry and NMR spectroscopy to identify both the effect of LiBr as an additive as well as the purpose of 3-dimethyl-2-imidazolidinone (DMI) as a co-solvent. The results suggest that the main role of DMI is to facilitate a higher order bromozincate formation during the addition of LiBr. |
| Keywords: | additives cross‐ coupling Negishi cross‐coupling organozincate palladium zinc |
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