Quantum dots as contrast agents for in vivo tumor imaging: progress and issues |
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Authors: | Anthony J Tavares Lori Chong Eleonora Petryayeva W Russ Algar Ulrich J Krull |
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Institution: | (1) Chemical Sensors Group Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, ON, L5L 1C6, Canada; |
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Abstract: | Quantum dots (QDs) have shown promise as imaging agents in cancer, heart disease, and gene therapy research. This review focuses
on the design of QDs, and modification using peptides and proteins for mediated targeting of tissues for fluorescence imaging
of tumors in vivo. Recent examples from the literature are used to illustrate the potential of QDs as effective imaging agents.
The distribution and ultimate fate of QDs in vivo is considered, and considerations of designs that minimize potential toxicity
are presented. |
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