| 超声液相萃取-GC/MS-SIM法定量检测唾液中苯丙胺类毒品 |
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| 引用本文： | 王燕燕,孟品佳.超声液相萃取-GC/MS-SIM法定量检测唾液中苯丙胺类毒品[J].分析试验室,2009,28(3). |
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| 作者姓名： | 王燕燕 孟品佳 |
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| 作者单位： | 中国人民公安大学刑事科学技术系,北京,100038 |
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| 基金项目： | 北京市教委共建项目建设计划 |
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| 摘 要： | 建立了一种人体唾液中苯丙胺(AM)、甲基苯丙胺(MAM)、 3, 4-亚甲二氧基苯丙胺(MDA)、 3, 4-亚甲二氧基甲基苯丙胺(MDMA)毒品的超声波液液萃取-气相色谱/质谱-选择离子检测方法. 对萃取溶剂、萃取时间等参数进行了考查, 确定了乙酸乙酯为萃取溶剂, 在超声波下液液萃取2 min. 用该溶剂对添加毒品的唾液进行提取, 采用气相色谱/质谱-选择离子检测法(GC/MS-SIM)检测, 获得了良好线性, 相对标准偏差在15%内, 准确性均在80%～115%之间, 最小检测限可达0.05 μg/mL. 该方法未对毒品进行衍生化处理, 可用于缴获毒品及嫌疑吸毒者人体生物检材中苯丙胺类毒品的分析.
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| 关 键 词： | 苯丙胺类毒品 GC/MS-SIM检测 液相萃取 超声波萃取 |
Determination of amphetamines in saliva by gas chromatography/selected ion monitoring-mass spectrometry |
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| WANG Yan-yan,MENG Pin-jia.Determination of amphetamines in saliva by gas chromatography/selected ion monitoring-mass spectrometry[J].Chinese Journal of Analysis Laboratory,2009,28(3). |
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| Authors: | WANG Yan-yan MENG Pin-jia |
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| Abstract: | In the present work, a method for the detection of amphetamine (AM), methamphetamine (MAM), 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenemethamphtamine (MDMA) in human saliva using ultrasound liquid-liquid extraction-gas chromatography/mass spectrometry-selected ion monitoring was developed. Some extraction parameters such as extraction solvent, ultrasound time were investigated. Ethyl acetate was chosen as solvent to extract the drugs from the biological fluid. The method was used for spiked saliva an... |
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| Keywords: | Amphetamines GC/MS-SIM detection Liquid-phase extraction Ultrasound extraction |
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