Evaluation of MRI fat fraction in the liver and spine pre and post SPIO infusion |
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| Authors: | Joy Liau Masoud Shiehmorteza Olivier M Girard Claude B Sirlin Mark Bydder |
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| Institution: | 1. University of California San Diego, San Diego, CA 92103 – 8226, USA;2. Centre de Résonance Magnétique Biologique et Médicale, UMR 7339 CNRS – Faculté de Médecine, 13385 Marseille Cedex 05, France |
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| Abstract: | This study evaluates the robustness of a magnetic resonance (MR) fat quantification method to changes in R2* caused by an intravenous infusion of superparamagnetic iron oxide (SPIO) contrast agent. The R2* and proton density fat fraction (PDFF) were measured in liver and spine in 14 subjects using an investigational sequence (IDEAL IQ) provided by the MR scanner vendor. Measurements were made before and after SPIO infusion. Results showed SPIO significantly increased R2* in both liver (p = 8.8 × 10− 8) and spine (p =1.3 × 10− 2) but PDFFs were not significantly different in either the liver (p = 5.5 × 10− 1) or the spine (p = 5.6 × 10− 1). These results confirm that the IDEAL IQ method of fat quantification is robust to changes in R2*. |
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| Keywords: | Liver Spine MRI Fat fractionSPIO SPIO |
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