Design,synthesis and in vitro evaluation of tetrahydropyrimidine-isatin hybrids as potential antitubercular and antimalarial agents |
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| Authors: | Tarunkumar Nanjibhai Akhaja Jignesh Priyakant Raval |
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| Affiliation: | Department of Pharmaceutical Chemistry, Ashok & Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences (ARIBAS), New Vallabh Vidyanagar-388121, India |
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| Abstract: | A series of 5-substituted-3-[{5-(6-methyl-2-oxo/thioxo-4-phenyl-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl}-imino] -1,3-dihydro-2H-indol-2-one were synthesized,characterized and screened for their anti-tubercular and antimalarial activity. |
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| Keywords: | Tetrahydropyrimidines-isatin hybrid Biginelli reaction In vitro antitubercular Antimalarial activity |
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