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The highly enantioselective Diels-Alder reaction of 1,2-dihydropyridine using chiral cationic palladium-phosphinooxazolidine catalyst for the synthesis of chiral isoquinuclidines |
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| Authors: | Hiroto Nakano Natsumi Tsugawa Reiko Fujita |
| Affiliation: | Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan |
| Abstract: | The enantioselective Diels-Alder reactions of 1-phenoxycarbonyl-1,2-dihydropyridine with 1-alkylated acryloyl-pyrazolidin-3-ones using chiral cationic palladium-phosphinooxazolidine (Pd-POZ) catalyst afforded chiral isoquinuclidines with excellent enantioselectivity (up to 97% ee). |
| Keywords: | Enantioselective Diels-Alder reaction 1,2-Dihydropyridine Chiral cationic palladium-phosphinooxazolidine catalyst Chiral isoquinuclidines |
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