Michael addition reactions of acetoacetates and malonates with acrylates in water under strongly alkaline conditions |
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| Authors: | Michiko Iwamura Yuka Gotoh Tomoyuki Hashimoto Reiko Sakurai |
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| Institution: | Department of Biomolecular Science, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan |
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| Abstract: | Michael addition reactions of acetoacetates and malonates with acrylates in a 5 M KOH aqueous solution without using any other catalysts are described. When they are either tert-butyl or benzyl esters, the reaction proceeded very rapidly to afford moderate to high yields of the corresponding bis-Michael adducts that are unexpectedly stable under these conditions. |
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| Keywords: | Michael reactions 5 M KOH aqueous solution Acetoacetate Malonate Acrylate |
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