Asymmetric Michael addition of glycine imines via quaternary ammonium ion catalysis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Asymmetric Michael addition of glycine imines via quaternary ammonium ion catalysis

Authors:	Barry Lygo Bryan Allbutt Eirene H.M. Kirton

Affiliation:	School of Chemistry, University of Nottingham, Nottingham NG7 2RD, UK

Abstract:	The asymmetric Michael addition of glycine imine esters to simple α,β-unsaturated ketones via PTC is investigated. It is found that by employing 1 mol % of a chiral quaternary ammonium salt, derived from α-methylnaphthylamine in conjunction with Cs₂CO₃, high enantioselectivities can be obtained in conjugate additions involving simple alkylvinylketones.

Keywords:	Phase-transfer catalysis Michael addition Amino acids
本文献已被 ScienceDirect 等数据库收录！