Oxazoline as a useful tool in organic synthesis: preparation of 4-aryl-1,2,3,4-tetrahydroisoquinoline alkaloid skeleton |
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| Authors: | Julio A. Seijas |
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| Affiliation: | Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Santiago de Compostela, Aptdo. 280, 27080 Lugo, Spain |
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| Abstract: | New direct strategy for the synthesis of 4-aryl-1,2,3,4-tetrahydroisoquinolines. The key steps are based on oxazoline chemistry: nucleophilic substitution in an ortho-methoxyphenyloxazoline with a Grignard reagent and a 1,6-conjugate addition of a lithium amide to o-styrylphenyloxazoline. |
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| Keywords: | 4-Aryl-1,2,3,4-tetrahydroisoquinoline 1,6-Conjugate addition 2-Oxazoline |
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