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Studies towards the total synthesis of Sch 56036; isoquinolinone synthesis and the synthesis of phenanthrenes |
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| Authors: | Edward R Walker |
| Institution: | Department of Chemistry, Imperial College London, London SW7 2AZ, England, UK |
| Abstract: | The isoquinolinone hemisphere of Sch 56036 has been prepared using a modified Pomeranz-Fritsch reaction and the synthesis of the phenanthrene core has been modelled via a Suzuki coupling and subsequent ring closing metathesis. |
| Keywords: | Sch 56036 Albofungin Antifungal natural product Pomeranz-Fritsch reaction Palladium(0) coupling Ring closing metathesis Phenanthrene |
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