Cu-nanoparticles: a chemoselective catalyst for the aza-Michael reactions of N-alkyl- and N-arylpiperazines with acrylonitrile |
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| Authors: | Akhilesh K Verma Rupesh Kumar Amit Saxena Subho Mozumdar |
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| Institution: | a Synthetic Organic Chemistry Research Laboratory, Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi 110007, India
b Department of Chemistry, University of Delhi, Delhi 110007, India |
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| Abstract: | A novel method for effecting the aza-Michael reactions of N-alkyl- and N-arylpiperazines with acrylonitrile using Cu-nanoparticles is described. The method features the use of 10 mol % Cu (14-17 nm) nanoparticles under mild reaction conditions to afford the addition products in good to excellent yields. The Cu-nanoparticles selectively catalysed the aza-Michael reaction of N-alkyl- and N-arylpiperazines in the presence of aromatic amino or aliphatic hydroxy groups. |
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| Keywords: | Cu-nanoparticles Aza-Michael reaction Piperazine Cyanoethylation Acrylonitrile |
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