Synthesis of new chiral ionic liquids from natural acids and their applications in enantioselective Michael addition |
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| Authors: | Zhiming Wang Yu Zhang |
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| Affiliation: | a Zhejiang University, Xi Xi Campus, Department of Chemistry, Hangzhou, Zhejiang 310028, China
b Ningbo University, Department of Chemistry, Ningbo, Zhejiang 315211, China |
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| Abstract: | Two kinds of novel chiral ionic liquids based on imidazolium have been synthesized from chiral pool by a simple and straightforward procedure in good overall yields (44-60%). The application of CILs as reaction media in the enantioselective Michael addition of diethyl malonate to 1,3-diphenyl-prop-2-en-1-one has also been studied (yield 90-96%, 10-25% ee). |
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