One-pot synthesis of aza-Morita-Baylis-Hillman adducts from α-oxo ketene-S,S-acetals, arylaldehydes and nitriles |
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| Authors: | Shaoguang Sun Qun Liu Jing Kang Yanbing Yin Dongwei Li Dewen Dong |
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| Institution: | Department of Chemistry, Northeast Normal University, Changchun 130024, China |
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| Abstract: | Promoted by TiCl4, a series of α-(1,3-dithiolan-2-ylidene)-β-amino carbonyl derivatives--the aza-Morita-Baylis-Hillman adducts, have been synthesized from α-oxo cyclic ketene-S,S-acetals, arylaldehydes, and nitriles in good to excellent yields. A mechanism involving sequential Morita-Baylis-Hillman and Ritter reactions for this novel one-pot, three-component reaction is described. |
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| Keywords: | α-Oxo ketene-S S-acetals Aza-Morita-Baylis-Hillman adducts Ritter reaction One-pot three-component reaction |
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