Synthesis of a boronated amino acid as a potential neutron therapy agent: 1-amino-3-[(dihydroxyboryl)ethyl]cyclobutanecarboxylic acid |
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| Authors: | George W. Kabalka Min-Liang Yao Abhijit Navarane |
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| Affiliation: | Departments of Chemistry and Radiology, The University of Tennessee, Knoxville, TN 37996-1600, USA |
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| Abstract: | ![]()
A novel boronated aminocyclobutanecarboxylic acid was synthesized in 10 steps for potential use in neutron capture therapy. The molecule was modeled after the unnatural amino acid 1-aminocyclobutanecarboxylic acid, which has shown high uptake in brain tumors. |
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| Keywords: | Boronic acid Amine borane Amino acid Cyclobutane derivative |
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