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Synthesis of 3,4-disubstituted 2,5-dihydrofurans starting from the Baylis-Hillman adducts via consecutive radical cyclization, halolactonization, and decarboxylation strategy
Authors:Saravanan Gowrisankar
Affiliation:Department of Chemistry and Institute of Basic Science, Chonnam National University, Gwangju 500-757, South Korea
Abstract:
A facile synthetic method of 3,4-disubstituted 2,5-dihydrofurans and 2,5-dihydropyrroles starting from the Baylis-Hillman adducts was developed. The 2,5-dihydrofuran skeleton was constructed via the consecutive radical cyclization, hydrolysis, halolactonization, and spontaneous decarboxylation strategy starting from the modified Baylis-Hillman adducts.
Keywords:2,5-Dihydrofurans   Radical cyclization   Halolactonization   Baylis-Hillman adducts
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