Copper-catalyzed coupling of aryl halides and nitrite salts: a mild Ullmann-type synthesis of aromatic nitro compounds |
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| Authors: | Shinichi Saito Yuichiro Koizumi |
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| Institution: | Department of Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku, Tokyo 162-8601, Japan |
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| Abstract: | Nitration of aromatic halides proceeded smoothly in the presence of catalytic amounts of Cu bronze and N,N′-dimethylethylenediamine. Sodium nitrite-18-crown-6, or tetra-n-butylammonium nitrite (n-Bu4NNO2) turned out to be efficient nitrating agents. The aromatic nitro compounds were synthesized under essentially neutral conditions. |
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| Keywords: | Nitration Copper catalyst Aryl iodide Nitroarenes Nitrites |
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