1. The CAS Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, China;2. The Graduate School of Chinese Academy of Sciences, Beijing 100049, China
Abstract:
An amphiphilic diblock copolymer PG‐b‐PCL with well‐controlled structure and pendant hydroxyl groups along hydrophilic block was synthesized by sequential anionic ring‐opening polymerization. The micellization and drug release of PG‐b‐PCL copolymers using pyrene as a fluorescence probe were investigated for determining the influences of copolymer composition and lipase concentration on drug loading capacity and controlled release behavior. The biodegradation of PG‐b‐PCL copolymers was studied with microspheres as research samples. It has been concluded that the polar hydroxyl groups along each repeat unit of hydrophilic PG block in PG‐b‐PCL copolymer have great influences on drug encapsulation, drug release, and enzymatic degradation of micelles and microspheres.
