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Complexation of aminoglutethimide with native and modified cyclodextrins
Authors:Michal Nowakowski  Maciej Dlugosz  Joanna Taraszewska  Jacek Wojcik
Affiliation:1. Polish Academy of Sciences, Institute of Biochemistry and Biophysics, Warsaw, Poland;2. Institute of Biochemistry and Biophysics, PAS Laboratory of Biological NMR, Warszawa, Poland
Abstract:
Complexations of R(+) and RS(+/?)aminoglutethimide (AGT), the drug used in a treatment of breast and prostate cancer with native and modified cyclodextrins (α‐CD, β‐CD, γ‐CD, 2,6‐di‐O‐methyl‐β‐CD (DM‐β‐CD), 2,3,6‐tri‐O‐methyl‐β‐CD (TM‐β‐CD) and carboxymethyl‐β‐CD (CM‐β‐CD)) were studied. The stability constants were determined with UV–Vis spectrophotometric method at pH 9.0. The NMR data obtained for TM‐β‐CD suggest that the complexation of AGT is possible from both sides of CD molecule. This was confirmed by molecular dynamic simulations. Copyright © 2009 John Wiley & Sons, Ltd.
Keywords:aminoglutethimide  cyclodextrins  complexation  NMR  molecular  dynamics
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