Fluorine-containing pH-responsive core/shell microgel particles: preparation,characterization, and their applications in controlled drug release |
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| Authors: | Guoqiang?Liu Xiaolong?Li Shengdong?Xiong Ling?Li Paul?K?Chu Kelvin?W?K?Yeung Shuilin?Wu Email author" target="_blank">Zushun?XuEmail author |
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| Institution: | (1) Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei University, Wuhan, 430062, People’s Republic of China;(2) Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, People’s Republic of China;(3) Division of Spine Surgery, Department of Orthopaedics and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong, People’s Republic of China |
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| Abstract: | A kind of novel fluorine-containing pH-responsive core/shell microgels poly(DMAEMA-co-HFMA)-g-PEG were prepared via surfactant-free emulsion polymerization using water as the solvent. The well-defined chemical structure
of the copolymers was characterized by FTIR, 1H-NMR, 19F-NMR, and elemental analysis. The microgel particles were studied by florescence probe technique, dynamic light scattering,
and zeta potential measurement; the microgels displayed a significant pH-responsive behavior. Furthermore, the cytotoxicity
assay indicated that the copolymer microgels had low toxicity, and 5-FU-loaded microgels offered a certain killing potency
against cancer cells. In addition, the drug loading and in vitro drug release demonstrated that 5-FU was successfully incorporated
into polymeric microgels, and the drug-loaded microgels showed a marked pH-dependent drug release behavior. This study suggests
that the poly(DMAEMA-co-HFMA)-g-PEG microgels play an important role in the release mechanism stimulated by the change in the pH and have potential applications
as a controlled drug release carrier. |
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