Simple and efficient cleavage reaction of the boc group in heterocyclic compounds |
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Authors: | Klai Nadia Berredjem Malika Khettache Nawel Belghit Med Yazid Rgaïnia Zine Nour‐Eddine Aouf |
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Institution: | Klai Nadia,Berredjem Malika,Khettache Nawel,Belghit Med Yazid,Régaïnia Zine,Nour‐Eddine Aouf |
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Abstract: | Dedicated to the memory of Pr. Ladjama Daif A series of chiral cyclosulfamides have been synthesized by alkaline cyclisation starting from N‐benzoylamino acids (Ala, Val, Leu, Phe) derivatives and chlorosulfonyl isocyanate. A simplified and regioselective deprotection of the cyclic compounds (cyclosulfamides) containing the tert‐butyloxycarbonyl group (Boc) has been achieved in good yield by fusion under reduced pressure. |
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