Regioselectivity of Alkylation of 3-Substituted 5-Amino-1,2,4-thiadiazoles |
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| Authors: | M. Khakimov R. F. Ambartsumova B. Tashkhodzhaev M. Yu. Antipin Kh. M. Shakhidoyatov |
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| Affiliation: | (1) Acad. S. Yunusov Institute of Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, 700170 |
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| Abstract: | ![]()
We have synthesized 3-substituted 4-alkyl-5-imino-4,5-dihydro-1,2,4-thiadiazoles by reaction of 3-alkyl(benzyl)thio-5-amino-1,2,4-thiadiazoles with methyl iodide or ethylene chlorohydrin. In the reaction with epichlorohydrin, addition of an oxirane molecule occurs with formation of tetrahydropyrimido[2,1-b]-1,2,4-thiadiazoles. |
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| Keywords: | 4-alkyl-5-imino-4,5-dihydro-1,2,4-thiadiazoles 5-amino-1,2,4-thiadiazoles tetrahydropyrimido[2,1-b]-1,2,4-thiadiazoles ethylene chlorohydrin epichlorohydrin X-ray diffraction |
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