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Tyrosine nitration of human ERK1 introduces an intra-hydrogen bond by molecular dynamics simulations |
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| Authors: | Xu Wu Zhang Yuanya Achi Oliver Y Knierim Kathleen D Hanks Justin G Wang Yingchun |
| Institution: | 1.Department of Chemistry, University of Louisiana at Lafayette, Lafayette, LA, 70504, USA ;2.State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, No.1 West Beichen Rd., Beijing, 100101, China ; |
| Abstract: | Structural Chemistry - ERK1 is an important kinase in Ras–Raf–MEK signaling. We have recently demonstrated by mass spectrometry that Tyr210 of ERK1 can be nitrated, and the nitration... |
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