Poly(ethylene glycol) conjugated nano-graphene oxide for photodynamic therapy |
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| Authors: | HaiQing Dong ZhiLei Zhao HuiYun Wen YongYong yongyong_li@tongjieducn Li FangFang Guo AiJun Shen Frank Pilger Chao Lin DongLu Shi |
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| Institution: | 1. Institute for Advanced Materials and Nano Biomedicine (iNANO), Tongji University, Shanghai, 200092, China
2. Department of Chemical and Materials Engineering, University of Cincinnati, Cincinnati, OH, 45221, USA
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| Abstract: | A novel methoxy-poly(ethylene glycol) modified nano-graphene oxide (NGO-mPEG) was designed and synthesized as a photosensitizer (PS) carrier for photodynamic therapy of cancer. NGO with a size below 200 nm was prepared using a modified Hummers’ method. NGO was observed by AFM to exhibit a structure with single-layer graphene oxide sheets down to a few nanometers in height. Hydrophilic mPEG conjugation of NGO (NGO-mPEG) was found to enhance solubility in cell culture media. No apparent cytotoxicity of the NGO-mPEG was observed towards MCF-7 carcinoma cell line. Zinc phthalocyanine (ZnPc), a photosensitizer for photodynamic therapy, was loaded in the NGO-PEG through π-π stacking and hydrophobic interactions, with the drug loading efficiency up to 14 wt%. Hydrophobic ZnPc was internalized in MCF-7 cells, exhibiting a pronounced phototoxicity in the cells under Xe light irradiation. The results indicate a great potential of NGO-mPEG for photodynamic therapy of cancer. |
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