Synthesis and antioxidant properties of some new thiazolyl coumarin derivatives |
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| Authors: | Donia Bensalah Aziza Mnasri A. Chakchouk-Mtibaa Lamjed Mansour L. Mellouli |
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| Affiliation: | 1. Research Laboratory of Environmental Sciences and Technologies (LR16ES09), Higher Institute of Environmental Sciences and Technology, University of Carthage, Hammam-Lif, Tunisia;2. Laboratory of Microorganisms and Biomolecules of the Center of Biotechnology of Sfax-Tunisia, Sfax, Tunisia;3. Zoology Department, College of Science, King Saud University, Saudi Arabia, Riyadh, Saudi Arabia |
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| Abstract: | ABSTRACT A three-component one-pot synthesis of new thiazolyl coumarin derivatives was carried out by condensing 3-acetyl-4-hydroxycoumarin, arylaldehydes, thiourea and ammonium acetate at reflux in DMC. The optimization details of the developed novel protocol are recorded. In addition, we have also synthesized these compounds via another second route in two steps. High atom-economy, excellent yields, simple procedure, and mild reaction conditions are the important features of this one-pot protocol. The chemical structures of the newly synthesized compounds were elucidated by using analytical (IR, 1H NMR, 13C NMR). Further, all the compounds were screened for their antioxidant activities. |
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| Keywords: | 3-acetyl-4-hydroxycoumarin multicomponent reactions biological activities |
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