Effects of information transmission delay and channel blocking on synchronization in scale-free Hodgkin-Huxley neuronal networks |
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Authors: | Qing-Yun Wang and Yan-Hong Zheng |
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Institution: | Qing-Yun Wang·Yan-Hong Zheng Department of Dynamics and Control,Beihang University,100191 Beijing,China School of Mathematics and Computer Science,Fujian Normal University,350007 Fuzhou,China |
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Abstract: | In this paper, we investigate the evolution of spatiotemporal patterns and synchronization transitions in dependence on the
information transmission delay and ion channel blocking in scale-free neuronal networks. As the underlying model of neuronal
dynamics, we use the Hodgkin-Huxley equations incorporating channel blocking and intrinsic noise. It is shown that delays
play a significant yet subtle role in shaping the dynamics of neuronal networks. In particular, regions of irregular and regular
propagating excitatory fronts related to the synchronization transitions appear intermittently as the delay increases. Moreover,
the fraction of working sodium and potassium ion channels can also have a significant impact on the spatiotemporal dynamics
of neuronal networks. As the fraction of blocked sodium channels increases, the frequency of excitatory events decreases,
which in turn manifests as an increase in the neuronal synchrony that, however, is dysfunctional due to the virtual absence
of large-amplitude excitations. Expectedly, we also show that larger coupling strengths improve synchronization irrespective
of the information transmission delay and channel blocking. The presented results are also robust against the variation of
the network size, thus providing insights that could facilitate understanding of the joint impact of ion channel blocking
and information transmission delay on the spatiotemporal dynamics of neuronal networks. |
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Keywords: | Scale-free neuronal networks · Information transmission delay · Ion channel blocking · Synchronization |
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