| Studies on the Physicochemical Properties, Structure and Antitumor Activity of an Oligosaccharide Homologue SnS-2 from the Root of Scrophularia ningpoensis Hemsh |
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| 引用本文： | 邓军娥 张健 陈晓明 柯炜 田庚元. Studies on the Physicochemical Properties, Structure and Antitumor Activity of an Oligosaccharide Homologue SnS-2 from the Root of Scrophularia ningpoensis Hemsh[J]. 中国化学, 2004, 22(5): 492-497. DOI: 10.1002/cjoc.20040220520 |
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| 作者姓名： | 邓军娥 张健 陈晓明 柯炜 田庚元 |
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| 作者单位： | StateKeyLaboratoryofBio-organic＆NaturalProductsChemistry,ShanghaiInstituteofOrganicChemistry,ChineseAcademyofSciences,Shanghai200032,China |
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| 摘 要： | An oligosaccharide homologue named SnS-2 was isolated from the root of Scrophularia ningpoensis Hemsl.SnS-2 was purified by means of gel-permeation chromatography and ion-exchange chromatography. Its physicochemical properties, including carbohydrate content and molecular weight were determined. The structure of SnS-2 was elucidated by chemical methods along with ^1H and ^13C NMR spectroscopy, including two-dimensional DQCOSY and H-detected ^1H, ^13C HMQC experiments. These results show that SnS-2 possesses a backbone consisting of terminal α-Galp-(1→, α-Galp-(1→6), α-Glcp-(1→6) and nonreducing end β-Fruf-(2→. The bioactive assay showed that it could inhibit the growth of Lewis pulmonary carcinoma implanted in mice.
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| 关 键 词： | 物理化学性质 结构 抗癌活性 寡糖 SnS-2 玄参科 根部 提取 肺癌 |
Studies on the Physicochemical Properties,Structure and Antitumor Activity of an Oligosaccharide Homologue SnS‐2 from the Root of Scrophularia ningpoensis Hemsl |
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| Jun‐E Deng,Jian Zhang,Xiao‐Ming Chen,Wei Ke,Geng‐Yuan Tian. Studies on the Physicochemical Properties,Structure and Antitumor Activity of an Oligosaccharide Homologue SnS‐2 from the Root of Scrophularia ningpoensis Hemsl[J]. Chinese Journal of Chemistry, 2004, 22(5): 492-497. DOI: 10.1002/cjoc.20040220520 |
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| Authors: | Jun‐E Deng Jian Zhang Xiao‐Ming Chen Wei Ke Geng‐Yuan Tian |
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| Abstract: | An oligosaccharide homologue named SnS‐2 was isolated from the root of Scrophularia ningpoensis Hemsl. SnS‐2 was purified by means of gel‐permeation chromatography and ion‐exchange chromatography. Its physico‐chemical properties, including carbohydrate content and molecular weight were determined. The structure of SnS‐2 was elucidated by chemical methods along with 1H and 13C NMR spectroscopy, including two‐dimensional DQCOSY and H‐detected 1H, 13C HMQC experiments. These. results show that SnS‐2 possesses a backbone consisting of terminal α‐Galp(1→, α‐Galp‐(1→6), α‐Glcp‐(1→6) and nonreducing end β‐Furf‐(2→. The bioactive assay showed that it could inhibit the growth of Lewis pulmonary carcinoma implanted in mice. |
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| Keywords: | Scrophularia ningpoensis Hemsl physicochemical property structure antitumor activity oligosaccharide homologue |
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