A facile pathway to prepare enzymatically degradable microcapsules with tunable capsule shell properties |
| |
Authors: | Zhongjun Wang Hui Zhu Wen Yang Xiaolei Wang Juan Wang Xiurong Yang |
| |
Institution: | aState Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China;bGraduate School of the Chinese Academy of Sciences, Beijing, 100039, China |
| |
Abstract: | Dextran sulfate (DS)/poly-l-lysine (PLL) microcapsules are fabricated by an in situ coacervation method using DS-doped CaCO3 microparticles as templates. Twinned superstructures or spherical CaCO3 microparticles are produced depending on DS concentration in the starting solution. DS/PLL microcapsules with ellipsoidal or spherical outline are obtained after removal of templates in disodium ethylene diamine tetraacetate dehydrate (EDTA) without PLL. Their shell thickness and negative surface charges increase with the DS weight percentage in the templates. The surface potential of DS/PLL microcapsules, fabricated by core removal in an EDTA/PLL solution, can be easily tuned by altering PLL concentration in template removal solution. DS/PLL microcapsules fabricated by template removal in solution with or without PLL are both degraded by α-chymotrypsin, and different degradation profiles are observed because of shell thickness differences. DS/PLL may be used as transport vehicles for various compounds regardless of their charge sign in biomedical fields. |
| |
Keywords: | Polyelectrolyte microcapsules Time-saving method Dextran sulfate l-lysine" target="_blank">Poly-l-lysine Enzyme biodegradation |
本文献已被 ScienceDirect 等数据库收录! |
|