6-O-(2-hydroxybutyl)-β-CD as a chiral selector for nonaqueous capillary electrophoretic separation of chiral drugs |
| |
Authors: | Wenguo Xing Yunhe Wei Ping Yu Changqiao Zhang Jian Li |
| |
Institution: | (1) School of Pharmacy, Second Military Medical University, Shanghai, 200433, China;(2) Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200433, China; |
| |
Abstract: | 6-O-(2-hydroxybutyl)-β-CD, as a new β-cyclodextrin (β-CD) derivative, was successfully synthesized. It was used as a chiral
selector to separate six chiral drugs, including propranolol, anisodamine, promethazine, ketoconazole, benzhexol, and fenfluramine
in nonaqueous capillary electrophoresis (NACE). The effects of the organic solvent, the electrolytes, the concentrations of
cyclodextrin derivatives, and the pH of the buffer on the chiral resolution (Rs) were investigated. The baseline separation
of enantiomers, including propranolol (Rs = 2.26), anisodamine (Rs = 2.31), promethazine (Rs = 2.42), ketoconazole (Rs = 2.56),
benzhexol (Rs = 3.38), and fenfluramine (Rs = 3.04), could be achieved using a buffer of 100 mmol · Lt−1 citric acid and 50 mmol · Lt−1 Tris (hydroxymethyl) aminomethane (Tris) at pH 4.6 containing 100 mmol · Lt−1 6-O-(2-hydroxybutyl)-β-CD in formamide (FA). |
| |
Keywords: | |
本文献已被 万方数据 SpringerLink 等数据库收录! |
|