Microwave-assisted parallel synthesis of fused heterocycles in a novel parallel multimode reactor |
| |
Authors: | Treu Matthias Karner Thomas Kousek Roland Berger Helmut Mayer Moriz McConnell Darryl B Stadler Alexander |
| |
Institution: | Boehringer Ingelheim Austria GmbH, Dr. Boehringer Gasse 5-11, A-1121 Vienna, Austria. |
| |
Abstract: | New rotor types using disposable glass vials for small-scale parallel synthesis in multimode microwave reactors are introduced. One rotor comprises 16 groups of four vials, whereas the second uses four silicon carbide plates with a 6 x 4 matrix to process the vials. Both rotors achieve utmost temperature homogeneity upon microwave irradiation and can be used for microwave-mediated reactions at temperatures of up to 200 degrees C and pressures of 20 bar. The generation of three different heterocycle libraries furnishing thiophenes, oxindoles, and benzimidazoles using the new rotor types is described. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|