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Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2
Authors:Nishikimi Akihiko  Uruno Takehito  Duan Xuefeng  Cao Qinhong  Okamura Yuji  Saitoh Takashi  Saito Nae  Sakaoka Shunsuke  Du Yao  Suenaga Atsushi  Kukimoto-Niino Mutsuko  Miyano Kei  Gotoh Kazuhito  Okabe Takayoshi  Sanematsu Fumiyuki  Tanaka Yoshihiko  Sumimoto Hideki  Honma Teruki  Yokoyama Shigeyuki  Nagano Tetsuo  Kohda Daisuke  Kanai Motomu  Fukui Yoshinori
Affiliation:Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.
Abstract:
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  • Highlights? CPYPP binds to DOCK2 DHR-2 domain and inhibits its catalytic activity ? CPYPP inhibits DOCK2-mediated Rac activation in cells ? The structural features of CPYPP required for its inhibitory effect were revealed ? CPYPP inhibits lymphocyte migration and activation in vitro and in vivo
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