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Recovery of 177Lu from Irradiated HfO2 Targets for Nuclear Medicine Purposes |
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| Authors: | Andrey G. Kazakov Taisya Y. Ekatova Julia S. Babenya Sergey S. Belyshev Vadim V. Khankin Alexander A. Kuznetsov Sergey E. Vinokurov Boris F. Myasoedov |
| Affiliation: | 1.Radiochemistry Laboratory, Vernadsky Institute of Geochemistry and Analytical Chemistry of the Russian Academy of Sciences (GEOKHI RAS), Kosygin St., 19, 119991 Moscow, Russia; (T.Y.E.); (J.S.B.); (S.E.V.); (B.F.M.);2.Skobeltsyn Institute of Nuclear Physics, Lomonosov Moscow State University, Leninskie Gory, 1, Bld. 2, 119991 Moscow, Russia; (S.S.B.); (V.V.K.); (A.A.K.);3.Department of Physics, Lomonosov Moscow State University, Leninskie Gory, 1, Bld. 2, 119991 Moscow, Russia |
| Abstract: | A new method of production of one of the most widely used isotopes in nuclear medicine, 177Lu, with high chemical purity was developed; this method includes irradiation of the HfO2 target with bremsstrahlung photons. The irradiated target was dissolved in HF and then diluted and placed onto a column filled with LN resin. Quantitative sorption of 177Lu could be observed during this process. The column later was rinsed with the mixture of 0.1 M HF and 1 M HNO3 and then 2 M HNO3 to remove impurities. Quantitative desorption of 177Lu was achieved by using 6 M HNO3. The developed method of 177Lu production ensures high purification of this isotope from macroquantities of hafnium and zirconium and radioactive impurities of carrier-free yttrium. The content of 177mLu in 177Lu in photonuclear production was determined. Due to high chemical and radionuclide purity, 177Lu obtained by the developed method can be used in nuclear medicine. |
| Keywords: | 177Lu extraction chromatography photonuclear reactions radiochemical recovery nuclear medicine |