Synthetic study of diversifolin: the construction of 11-oxabicyclo[6.2.1]undec-3-ene core using ring-closing metathesis |
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| Authors: | Nakamura Tomoaki Oshida Motoko Nomura Tomoko Nakazaki Atsuo Kobayashi Susumu |
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| Institution: | Faculty of Pharmaceutical Sciences, Tokyo University of Science (RIKADAI), 2641 Yamazaki, Noda-shi, Chiba 278-8510, Japan. |
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| Abstract: | Stereoselective synthesis of a potential intermediate bearing 11-oxabicyclo6.2.1]undec-3-ene core, a common scaffold of biologically active germacrane-type sesquiterpenes, has been achieved. Synthetic features involve formal 1,3-asymmetric induction, unusual ring-closing metathesis constructing a 10-membered carbocycle system, and unique lactone transposition. |
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