Transition-metal-catalyzed CH functionalization for late-stage modification of peptides and proteins |
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| Authors: | Xi Lu Shi-Jiang He Wan-Min Cheng Jing Shi |
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| Institution: | Hefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory of Urban Pollutant Conversion, Anhui Province Key Laboratory of Biomass Clean Energy, iChEM, University of Science and Technology of China, Hefei 230026, China |
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| Abstract: | Late-stage modification of peptides and proteins meets the increasing demand in biochemical and pharmaceutical communities. These modification strategies could provide functionalized non-proteinogenic analogues with enhanced biological activities or improved therapeutic capabilities compared to their natural counterparts. Recent years, transition-metal-promoted functionalization of ubiquitous C | |
| Keywords: | Transition-metals Chemo- and site selective Late-stage modification Peptides and proteins |
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