Organocatalytic cascade 1,6-conjugate addition/annulation/tautomerization of functionalized para-quinone methides: Access to chiral 2-amino-4-aryl-4H-chromenes |
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| Authors: | Cong Duan Ling Ye Wenqin Xu Xinying Li Feng Chen Zhigang Zhao Xuefeng Li |
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| Affiliation: | a College of Chemistry and Environment Protection Engineering, Southwest Minzu University, Chengdu 610041, China;b Faculty of Geosciences and Environmental Engineering, Southwest Jiaotong University, Chengdu 610031, China |
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| Abstract: | A novel organocatalytic cascade process initiated by 1,6-conjugated addition has been successfully developed. A range of pharmaceutically active 2-amino-4-aryl-4H-chromenes were readily obtained in high yields (88%-99%) and excellent enantiopurities (86%-99% ee). The functionalized para-Quinone methides (p-OMs) could be facilely obtained. |
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| Keywords: | Domino reaction 1,6-Conjugated addition Enantioselective |
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