|
|||||
|
|
| Development of a potent peptide inhibitor of estrogen receptor α | |
| 作者姓名： | Xuan Qin Hui Zhao Yanhong Jiang Feng Yin Yuan Tian Mingsheng Xie Xiyang Ye Naihan Xu Zigang Li |
| 作者单位： | a School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen 518055, China; b School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 611756, China; c Department of Gynecology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen 518020, China; d Key Lab in Healthy Science and Technology, Division of Life Science, Shenzhen Graduate School of Tsinghua University, Shenzhen 518055, China |
| 基金项目： | We acknowledge financial support from the National Natural Science Foundation of China (Nos. 21778009 and 81701818; MOST2015DFA31590); the Shenzhen Science and Technology Innovation Committee (Nos. JCYJ20170412150719814 and GJHS20170310093122365). |
| 摘 要： | A potent peptide inhibitor of estrogen receptor α (ER-α) with significantly increased cellular uptake and cellular distribution was developed by cell penetrating peptide attachment. The resulted peptide conjugate showed selective toxicity towards estrogen receptor positive cell lines and induced decreased transcription of estrogen receptor α downstream genes. |
| 收稿时间： | 2018-01-20 |
| 本文献已被 CNKI ScienceDirect 等数据库收录！ | |
| 点击此处可从《中国化学快报》浏览原始摘要信息 | |
| 点击此处可从《中国化学快报》下载全文 | |