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A new cytotoxic salannin-class limonoid alkaloid from seeds of Azadirachta indica A. Juss |
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| Authors: | Jianxun Zhu Xiaofeng Lu Xiaona Fan Ruibo Wu Hongjuan Diao Rongmin Yu Hanhong Xu Jiachen Zi |
| Institution: | a Biotechnological Institute of Chinese Materia Medica, Jinan University, Guangzhou 510632, China; b College of Pharmacy, Jinan University, Guangzhou 510632, China; c School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China; d School of Pharmaceutical Science, Sun Yat-sen University, Guangzhou 510006, China; e State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou 510642, China |
| Abstract: | A new cytotoxic salannin-class limonoid alkaloid, azadiramide A (1), was isolated from seeds of Azadirachta indica A. Juss. Its structure was elucidated by extensive analysis of spectroscopic data and quantum chemical calculation. Compound 1 is a rare salannin-class limonoid alkaloid. To our best knowledge, only two compounds belonging to this type were so far found. It showed inhibitory activity against human breast cancer MDA-MB-231 cell line with IC50 value of 2.70 ± 0.63 μmol/L. |
| Keywords: | Limonoid Alkaloid Cytotoxic activity |
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