| 一种使用1,3-二溴-5,5-2甲基苯乙酮α-溴代新方法 |
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| 引用本文： | 高国锐,管细霞,邹新琢.一种使用1,3-二溴-5,5-2甲基苯乙酮α-溴代新方法[J].有机化学,2007,27(1):109-111. |
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| 作者姓名： | 高国锐 管细霞 邹新琢 |
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| 作者单位： | 华东师范大学化学系,上海,200062 |
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| 摘 要： | 报道了使用1,3-二溴-5,5-二甲基海因和对甲苯磺酸在甲醇中和20～60 ℃的温和条件下合成α-溴代苯乙酮的新方法. 对位和间位取代的苯乙酮获得了高的产率; 而在同样条件下, 邻位硝基苯乙酮没有发生反应.
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| 关 键 词： | α-溴代 苯乙酮 1 3-二溴-5 5-二甲基海因 |
| 收稿时间： | 2006-1-21 |
| 修稿时间： | 2006-02-22 |
A Novel Method for α-Bromination of Acetophenones Using 1,3-Dibromo-5,5-dimethylhydantoin |
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| GAO,Guo-Rui,GUAN,Xi-Xia,ZOU,Xin-Zhuo.A Novel Method for α-Bromination of Acetophenones Using 1,3-Dibromo-5,5-dimethylhydantoin[J].Chinese Journal of Organic Chemistry,2007,27(1):109-111. |
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| Authors: | GAO Guo-Rui GUAN Xi-Xia ZOU Xin-Zhuo |
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| Institution: | Department of Chemistry, East China Normal University, Shanghai 200062, China |
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| Abstract: | A novel method for the synthesis of α-bromoacetophenones by the reaction of 1,3-di-bromo- 5,5-dimethylhydantoin with p-toluenesulfonic acid in methanol at 20～60 ℃ was described. Substituted acetophenones at the para or meta position of aromatic ring gave α-bromoacetophenones in high yield. However reaction of o-nitroacetophenone did not take place under the same condition. |
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| Keywords: | α-bromination acetophenone 1 3-dibromo-5 5-dimethylhydantoins |
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