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Tonkinensines A and B, two novel alkaloids from Sophora tonkinensis |
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| Authors: | Xing-Nuo Li Zhi-Qiang Lu Hai-Xia Yan Shu-Hong Guan Hui-Ming Hua De-An Guo |
| Affiliation: | a Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 199 Guoshoujing Road, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China b School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, PR China |
| Abstract: | Tonkinensines A (1) and B (2), two novel cytisine-type alkaloids that feature the skeleton with a linkage to pterocarpan, were isolated from the roots of Sophora tonkinensis. Their structures and absolute configurations were elucidated by spectroscopic methods, especially X-ray crystal diffraction and CD spectral analysis. The proposed biosynthetic pathway was also discussed. Both 1 and 2 were tested in HeLa and MDA-MB-231 tumor cell lines, and compound 2 showed moderate cytotoxic activity. |
| Keywords: | Sophora tonkinensis Quinolizidine alkaloids Tonkinensine boldFont" >A Tonkinensine boldFont" >B |
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