NMR spectroscopic study of the inclusion complex of desloratadine with β-cyclodextrin in solution |
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| Authors: | Syed Mashhood Ali Santosh Kumar Upadhyay Arti Maheshwari |
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| Affiliation: | (1) Department of Chemistry, Aligarh Muslim University, Aligarh, 202002, UP, India |
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| Abstract: | Desloratadine (DES) is an antihistamine used in the treatment of allergies and chronic urticaria. 1H NMR spectroscopic study of varying ratios of DES and β-Cyclodextrin (β-CD) in D2O suggests the formation of a 1:1 inclusion complex formed by the penetration of Cl-substituted aromatic ring into the β-CD cavity. The stoichiometry and binding constant of the complex were determined by Scott’s method. |
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| Keywords: | Desloratadine β -Cyclodextrin Inclusion complex NMR spectroscopy ROESY COSY |
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