| 四个基于酰腙配体的双核苄基锡配合物的合成、晶体结构及体外抗癌活性 |
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| 引用本文： | 刘骄,李卓群,易雨阳,钟依欣,余浩田,谭宇星,蒋伍玖.四个基于酰腙配体的双核苄基锡配合物的合成、晶体结构及体外抗癌活性[J].无机化学学报,2019,35(12):2200-2208. |
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| 作者姓名： | 刘骄 李卓群 易雨阳 钟依欣 余浩田 谭宇星 蒋伍玖 |
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| 作者单位： | 衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 功能金属有机化合物湖南省重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 功能金属有机化合物湖南省重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 功能金属有机化合物湖南省重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 功能金属有机化合物湖南省重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 功能金属有机化合物湖南省重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 功能金属有机化合物湖南省重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 功能金属有机化合物湖南省重点实验室, 衡阳 421008 |
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| 基金项目： | 衡阳师范学院大学生课外学术科技作品重点项目（校科字[2019]2号-12）,湖南省大学生研究性学习和创新性实验计划项目（No.cx1813）,"功能金属有机材料"湖南省普通高等学校重点实验室开放基金项目（No.GN19K07）资助。 |
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| 摘 要： | 通过微波"一锅法"合成了4个双核苄基锡配合物:{C_4H_3S(O)C=N-N=C(Me)COO](PhCH_2)_2Sn(MeOH)}_2(C1)、{C_4H_3S(O)C=NN=C (Me)COO](p-Cl-C_6H_4CH_2)_2Sn (MeOH)}_2(C2)、{C_4H_3S (O)C=N-N=C (PhCH_2)COO](PhCH_2)_2Sn (MeOH)}_2(C3)、{C_4H_3S (O)C=N-N=C(PhCH_2)COO](p-Cl-C_6H_4CH_2)_2Sn(MeOH)}_2(C4),利用元素分析、IR、~1H NMR、~(13)C NMR、~(119)Sn NMR、HRMS以及X射线单晶衍射等表征了配合物结构。4个配合物分子均为双锡核分子,以Sn_2O_2四元环为中心对称,且中心锡原子与配位原子形成七配位畸变五角双锥构型。测试了配合物C1～C4的热稳定性以及配合物对癌细胞H460、HepG2、MCF7的体外抑制活性,结果表明:配合物C2是4个新合成的配合物中抑制癌细胞效果最好的化合物。
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| 关 键 词： | 有机锡配合物 酰腙 合成 晶体结构 抗癌活性 |
| 收稿时间： | 2019/6/27 0:00:00 |
| 修稿时间： | 2019/10/7 0:00:00 |
Syntheses, Crystal Structures and in Vitro Anticancer Activity of Four Binuclear Benzyltin Complexes Based on Acylhydrazone Ligand |
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| LIU Jiao,LI Zhuo-Qun,YI Yu-Yang,ZHONG Yi-Xin,YU Hao-Tian,TAN Yu-Xing and JIANG Wu-Jiu.Syntheses, Crystal Structures and in Vitro Anticancer Activity of Four Binuclear Benzyltin Complexes Based on Acylhydrazone Ligand[J].Chinese Journal of Inorganic Chemistry,2019,35(12):2200-2208. |
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| Authors: | LIU Jiao LI Zhuo-Qun YI Yu-Yang ZHONG Yi-Xin YU Hao-Tian TAN Yu-Xing and JIANG Wu-Jiu |
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| Institution: | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials, University of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China,Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials, University of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China,Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials, University of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China,Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials, University of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China,Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials, University of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China,Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials, University of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China and Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials, University of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China |
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| Abstract: | Four dinuclear benzyltin complexes were synthesized by microwave "one-pot synthesis", namely {C4H3S(O)C=N-N=C(Me)COO](PhCH2)2Sn(MeOH)}2 (C1), {C4H3S(O)C=N-N=C(Me)COO](p-Cl-C6H4CH2)2Sn(MeOH)}2 (C2), {C4H3S(O)C=N-N=C(PhCH2)COO](PhCH2)2Sn(MeOH)}2 (C3), {C4H3S(O)C=N-N=C(PhCH2)COO](p-Cl-C6H4CH2)2Sn(MeOH)}2 (C4). The complexes C1~C4 were characterized by IR, 1H NMR, 13C NMR 119Sn NMR spectra, elemental analysis, HRMS and the crystal structures were determined by X-ray diffraction. The four complexes are all binuclear molecules, and there was a Sn2O2 four-membered ring in the middle of the molecule. The central tin atom and the coordinating atom form a seven-coordinated pentagonal bipyramid configuration. The thermogravimetric of the complexes C1~C4 were analyzed, and in vitro antitumor activities of the complexes were evaluated by MTT against three human cancer cell lines (H460, HepG2, MCF7). The results show that complex C2 is the best compound for inhibiting cancer cells in the four synthesized complexes. |
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| Keywords: | organotin complex acylhydrazone synthesis crystal structure activity |
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