Incorporation of N-heterocyclic cations into proteins with a highly directed chemical modification |
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| Authors: | McMillan Nicola Smith Louise V de la Fuente Jesus M Parenty Alexis D C Gadegaard Nikolaj Pitt Andrew R Thomson Katrina Mackenzie Cameron Kelly Sharon M Cronin Leroy |
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| Affiliation: | WestCHEM, Department of Chemistry, The University of Glasgow, University Avenue, Glasgow, UK. |
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| Abstract: | ![]()
N-Heterocyclic cations are incorporated into proteins using 5-(2-bromoethyl)phenanthridinium bromide, which selectively reacts with either cysteine or lysine residues, resulting in ethylphenanthridinium (Phen) or highly stable cyclised dihydro-imidazo-phenanthridinium (DIP) adducts respectively; these modifications have been found to manipulate the observed structure of lysozyme and bovine serum albumin by AFM. |
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