Heck反应一锅法合成3-乙氧羰基-2-甲基吲哚的研究

吲哚以其独特的化学结构使其衍生出的化合物都具有独特的生理活性,它们在医药、农药、香料、色氨酸等领域发挥着重要的作用,是一类非常重要的杂环类精细化工中间体。因此,长久以来发展简单、通用,特别是具有区域选择性的方法合成吲哚类化合物一直吸引了人们的研究兴趣1]。在已经发展起来的合成吲哚类化合物的许多方法中,Heck反应2],即Pd催化卤代物与烯烃构筑碳碳键的方法,由于其温和的反应条件和广泛的官能团相容性,已经成为合成吲哚及其衍生物采用最多的方法3]。早在1984年,Suzuki4]就报道合成了化合物3-乙氧羰基-2-甲基吲哚,其是由…

Synthesis of 3-ethoxycarbonyl-2-methylindole through Heck reaction in one-pot

Because of the great virtue of Heck reaction and one-pot reaction,Recently it attract many attention that how to synthesis indoles by this two methods,and has gained many progress.But It is still a problem that how to synthesis indoles through one-pot reaction with o-haloaniline and open-chain ketone.Here,for the first time,we synthesized 3-ethoxycarbonyl-2-methylindole through one-pot Heck reaction with o-bromoaniline and open-chain ketone ethyl acetoacetate.Farther work is in progress.