| Convenient and Efficient Synthesis of L—Rhamnopyranosyl Phosphoramidates via H—Phosphonate |
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| 作者姓名： | Qi SUN Qiang XIAO Yong JU* Yu Fen ZHAO The Key Laboratory of Bioorganic Phosphorus Chemistry of Education Ministry |
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| 作者单位： | Qi SUN，Qiang XIAO，Yong JU*，Yu Fen ZHAO The Key Laboratory of Bioorganic Phosphorus Chemistry of Education Ministry，Department of Chemistry，School of Life Sciences and Engineering，Tsinghua University，Beijing 100084 |
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| 基金项目： | 国家自然科学基金，Tsinghua University |
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| 摘 要： | It is known that saccharides linked to proteins via a phosphoester hinge can function as immunological determinants. Under regular physiological conditions, it has been suggested that the role of phosphonate group is to direct the protease towards basic substrates1. Phosphoramidon a, which was isolated from a culture filtrate, is a potent inhibitor of the thermolysin, a metallo-endopeptidase. It is a glycosylated dipeptide, which has a L-rhamnose attached to the N-terminal of Leu-Trp dipep…
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Convenient and Efficient Synthesis of L-Rhamnopyranosyl Phosphoramidates via H-Phosphonate |
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| Qi SUN,Qiang XIAO,Yong JU*,Yu Fen ZHAO The Key Laboratory of Bioorganic Phosphorus Chemistry of Education Ministry,.Convenient and Efficient Synthesis of L-Rhamnopyranosyl Phosphoramidates via H-Phosphonate[J].Chinese Chemical Letters,2003,14(7):685-688. |
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| Authors: | Qi Sun Qiang XIAO Yong JU Yu Fen ZHAO |
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| Abstract: | The a-L-rhamnopyranosyl phosphomonoesters conjugated with L-amino acid methyl esters were stereoselectively synthesized in a convenient route by utilizing H-phosphonate intermediate. |
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| Keywords: | H-Phosphonate L-rhamnose phosphoramidate |
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