| 对羟基苯甲醛磷酸酯席夫碱衍生物的合成及其抗抑郁活性 |
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| 引用本文： | 刘进兵,吴凤艳. 对羟基苯甲醛磷酸酯席夫碱衍生物的合成及其抗抑郁活性[J]. 合成化学, 2015, 23(10): 934-937. DOI: 10.15952/j.cnki.cjsc.1005-1511.2015.10.0934 |
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| 作者姓名： | 刘进兵 吴凤艳 |
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| 作者单位： | LIU Jin-bing， WU Feng-yan |
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| 基金项目： | 邵阳学院创新团队资助项目 |
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| 摘 要： | 以对羟基苯甲醛为起始原料，经醚化和酯化反应制得中间体4-（2-羟乙氧基）苯甲醛磷酸二甲酯（2）； 2分别与伯胺经缩合反应合成了4个对羟基苯甲醛磷酸酯席夫碱衍生物（4a~4d）,其结构经1H NMR, 13C NMR, IR和ESI-MS确证。采用应急模型对4a~4d进行抗抑郁活性研究。初步结果表明： 2和4-（2-羟乙氧基）苯甲醛磷酸二甲酯甲氧基胺席夫碱（4d）表现出较好的抗抑郁活性，2的活性优于丙咪嗪，4d的活性与丙咪嗪接近。
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| 关 键 词： | 对羟基苯甲醛 磷酸酯 席夫碱 合成 抗抑郁活性 |
| 收稿时间： | 2015-03-17 |
Synthesis and Antidepressant Activities of 4-Hydroxybenzal-dehyde Schiff Base Derivatives with Phosphate Ester Group |
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| LIU Jin-bing,WU Feng-yan. Synthesis and Antidepressant Activities of 4-Hydroxybenzal-dehyde Schiff Base Derivatives with Phosphate Ester Group[J]. Chinese Journal of Synthetic Chemistry, 2015, 23(10): 934-937. DOI: 10.15952/j.cnki.cjsc.1005-1511.2015.10.0934 |
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| Authors: | LIU Jin-bing WU Feng-yan |
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| Affiliation: | Department of Biology and Chemical Engineering, Shaoyang University, Shaoyang 422000, China |
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| Abstract: | Four 4-hydroxybenzaldehyde Schiff base derivatives(4a~4d) with phosphate ester group were synthesized by condensation reaction of primary amine with 2-(4-formylphenoxy)ethyl dimethyl phosphate（2）, which was prepared by etherification and esterification from 4-hydroxybenzaldehyde. The structures were confirmed by 1H NMR, 13C NMR, IR and ESI-MS. Their antidepressant activities were investigated by emergency model. The results showed that 2 and 2-｛4-［(methoxyimino)methyl］phenoxy｝ethyl dimethyl phosphate（4d） had certain antidepressant activities in vivo. And 2 showed the better antidepressant activity than imipramine. |
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| Keywords: | 4-hydroxybenzaldehyde phosphate ester Schiff base synthesis antidepressant activity |
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