Synthesis of conjugates of lupane triterpenoids with chromane antioxidants and <Emphasis Type="Italic">in vitro</Emphasis> study of their influence on the production of nitrogen monoxide and on the arginase activity in activated macrophages |
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| Authors: | A Yu Spivak R R Khalitova Yu P Bel’skii A N Ivanova E R Shakurova N V Bel’skaya V N Odinokov M G Danilets A A Ligacheva |
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| Institution: | (1) Institute of Technical Chemistry, Ural Branch, Russian Academy of Sciences, 614013, Russia, Perm, ul. Akad. Koroleva, 3; |
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| Abstract: | Conjugates of lupane triterpenoids (betulin and betulonic and betulinic acids) with synthetic analogs of α-tocopherol were
obtained via ester bond formation and tested in vitro. Showing low cytotoxicity, some of them suppress nitrogen monoxide production without affecting the activity of arginase,
which suggests their antiinflammatory and immunomodulating properties. |
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